| | |  | | | | Record from Web of Science® | | | | | | |
| Obesity in patients with craniopharyngioma |
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| Author(s): Eyal O (Eyal, Ori), Sundararajan S (Sundararajan, Sumana), Inge TH (Inge, Thomas H.), Rose SR (Rose, Susan R.) |
| Source: ENDOCRINOLOGIST Volume: 16 Issue: 5 Pages: 286-293 Published: SEP-OCT 2006 |
| Times Cited: 4 References: 16 |
| Abstract: Craniopharyngioma is associated with increased risk for obesity. The risk is significantly increased after near total surgical intervention and/or radiation therapy. Among 16 patients diagnosed with craniopharyngioma in our center between 1993 and 2003, all but 3 developed obesity after surgery. We additionally detail 5 patients with craniopharyngioma diagnosed at ages 6 to 18 years who developed obesity after surgery and radiation therapy. The risk factors for obesity in patients with craniopharyngioma include hypothalamic damage as a result of the tumor itself, extent of surgery, and use of radiation therapy. Because the hypothalamus is a major neural center controlling food intake and body weight, damage to the ventromedial and lateral areas of the hypothalamus impairs regulation of appetite and energy expenditure, thus causing hypothalamic obesity. A variety of therapeutic approaches have been tried for hypothalamic obesity in patients with craniopharyngioma with limited success. These include controlling food intake and energy expenditure by lifestyle changes and antiobesity medications. Hence, there is a need for development of new. therapeutic strategies. In this article, we review current and some of the future therapeutic options. |
| Document Type: Review |
| Language: English |
| Reprint Address: Rose, SR (reprint author), Childrens Hosp, Med Ctr, Div Endocrine, MLC 7012,3333 Burnet Ave, Cincinnati, OH 45229 USA |
Addresses:
1. Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Chaim Sheba Med Ctr, Pediat Endocrinol & Diabet Unit,Sackler Sch Med, IL-69978 Tel Aviv, Israel
2. Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Div Pediat Endocrinol, Cleveland, OH 44106 USA
3. Univ Cincinnati, Med Ctr, Cincinnati Childrens Hosp, Div Pediat Endocrinol, Cincinnati, OH 45267 USA
4. Univ Cincinnati, Med Ctr, Cincinnati Childrens Hosp, Div Pediat Gen & Thorac Surg, Cincinnati, OH 45267 USA |
| Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
| Subject Category: Endocrinology & Metabolism |
| IDS Number: 093WR |
| ISSN: 1051-2144 |
| DOI: 10.1097/01.ten.0000240934.07504.bc |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |