| | |  | | | | Record from Web of Science® | | | | | | |
| Genomic signatures to guide the use of chemotherapeutics |
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| Author(s): Potti A (Potti, Anil), Dressman HK (Dressman, Holly K.), Bild A (Bild, Andrea), Riedel RF (Riedel, Richard F.), Chan G (Chan, Gina), Sayer R (Sayer, Robyn), Cragun J (Cragun, Janiel), Cottrill H (Cottrill, Hope), Kelley MJ (Kelley, Michael J.), Petersen R (Petersen, Rebecca), Harpole D (Harpole, David), Marks J (Marks, Jeffrey), Berchuck A (Berchuck, Andrew), Ginsburg GS (Ginsburg, Geoffrey S.), Febbo P (Febbo, Phillip), Lancaster J (Lancaster, Johnathan), Nevins JR (Nevins, Joseph R.) |
| Source: NATURE MEDICINE Volume: 12 Issue: 11 Pages: 1294-1300 Published: NOV 2006 |
| Times Cited: 191 References: 25 |
| Abstract: Using in vitro drug sensitivity data coupled with Affymetrix microarray data, we developed gene expression signatures that predict sensitivity to individual chemotherapeutic drugs. Each signature was validated with response data from an independent set of cell line studies. We further show that many of these signatures can accurately predict clinical response in individuals treated with these drugs. Notably, signatures developed to predict response to individual agents, when combined, could also predict response to multidrug regimens. Finally, we integrated the chemotherapy response signatures with signatures of oncogenic pathway deregulation to identify new therapeutic strategies that make use of all available drugs. The development of gene expression profiles that can predict response to commonly used cytotoxic agents provides opportunities to better use these drugs, including using them in combination with existing targeted therapies. |
| Document Type: Article |
| Language: English |
| Reprint Address: Nevins, JR (reprint author), Duke Univ, Duke Inst Gen Sci & Policy, Box 3383, Durham, NC 27710 USA |
Addresses:
1. Duke Univ, Duke Inst Gen Sci & Policy, Durham, NC 27710 USA
2. Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
3. Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA
4. Univ S Florida, Div Gynecol Surg Oncol, H Lee Moffitt Canc Ctr, Tampa, FL 33612 USA
5. Univ S Florida, Res Inst, Tampa, FL 33612 USA
6. Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
7. Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA |
| Publisher: NATURE PUBLISHING GROUP, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: 102WU |
| ISSN: 1078-8956 |
| DOI: 10.1038/nm1491 |
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