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| Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes |
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| Author(s): Cho YM (Cho, Young Min), Youn BS (Youn, Byung-Soo), Lee H (Lee, Hyewon), Lee N (Lee, Namseok), Min SS (Min, Sung-Shik), Kwak SH (Kwak, Soo Heon), Lee HK (Lee, Hong Kyu), Park KS (Park, Kyong Soo) |
| Source: DIABETES CARE Volume: 29 Issue: 11 Pages: 2457-2461 Published: NOV 2006 |
| Times Cited: 100 References: 16 |
| Abstract: OBJECTIVE - The dysregulation of adipokines is closely associated with the pathogenesis of insulin resistance and type 2 diabetes. Retinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide a link between obesity and insulin resistance. Here, we examined the relation between plasma RBP4 concentrations and various metabolic parameters in humans. RESEARCH DESIGN AND METHODS - An enzyme-linked immunosorbent assay was developed to measure human RBP4 plasma concentrations, which were then compared with various parameters related to insulin resistance in subjects with normal glucose tolerance (NGT; n = 57), impaired glucose tolerance (IGT; n = 48), and type 2 diabetes (n = 49).
RESULTS - Plasma RBP4 concentrations were higher in the IGT and type 2 diabetic groups than in the NGT group (median 18.9 [range 11.2-45.8], 20.9 [9.9-48.5], and 18.1 mu g/ml [9.3-30.5], respectively). However, no difference was found between plasma RBP4 concentrations in the IGT and type 2 diabetic groups. Plasma RBP4 concentrations were found to be associated with sex, waist circumference, fasting plasma glucose, and insulin resistance. Of these, sex and fasting plasma glucose levels were found to be independent determinants of plasma RBP4 concentration.
CONCLUSIONS - Plasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance.
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| Document Type: Article |
| Language: English |
| Reprint Address: Park, KS (reprint author), Seoul Natl Univ, Coll Med, Dept Internal Med, Chongno Gu, 28 Yongon Dong, Seoul 110744, South Korea |
Addresses:
1. Seoul Natl Univ, Coll Med, Dept Internal Med, Chongno Gu, Seoul 110744, South Korea
2. Seoul Natl Univ Hosp, Clin Res Inst, Genome Res Ctr Diabet & Endocrine Dis, Seoul 110744, South Korea
3. Korea Univ, Coll Life Sci & Biotechnol, Seoul 136701, South Korea
4. Univ Ulsan, Immunomodulat Res Ctr, Ulsan 680749, South Korea |
| Publisher: AMER DIABETES ASSOC, 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA |
| Subject Category: Endocrinology & Metabolism |
| IDS Number: 105LA |
| ISSN: 0149-5992 |
| DOI: 10.2337/dc06-0360 |
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