| | |  | | | | Record from Web of Science® | | | | | | |
| Myeloid C-type lectins in innate immunity |
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| Author(s): Robinson MJ (Robinson, Matthew J.), Sancho D (Sancho, David), Slack EC (Slack, Emma C.), LeibundGut-Landmann S (LeibundGut-Landmann, Salome), Sousa CRE (Sousa, Caetano Reis e) |
| Source: NATURE IMMUNOLOGY Volume: 7 Issue: 12 Pages: 1258-1265 Published: DEC 2006 |
| Times Cited: 112 References: 92 |
| Abstract: C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sousa, CRE (reprint author), London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England |
Addresses:
1. London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England |
| Publisher: NATURE PUBLISHING GROUP, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA |
| Subject Category: Immunology |
| IDS Number: 106TU |
| ISSN: 1529-2908 |
| DOI: 10.1038/ni1417 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |