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| Nucleotide excision repair disorders and the balance between cancer and aging |
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| Author(s): Andressoo JO (Andressoo, Jaan-Olle), Hoeijmakers JHJ (Hoeijmakers, Jan H. J.), Mitchell JR (Mitchell, James R.) |
| Source: CELL CYCLE Volume: 5 Issue: 24 Pages: 2886-2888 Published: DEC 15 2006 |
| Times Cited: 28 References: 33 |
| Abstract: Cancer incidence increases with age and is driven by accumulation of mutations in the DNA. In many so-called premature aging disorders, cancer appears earlier and at elevated rates. These diseases are predominantly caused by genome instability and present with symptoms, including cancer, resembling "segments" of aging and are thus often referred to as "segmental progerias". Two related segmental progerias, Cockayne syndrome (CS) and trichothiodystrophy (TTD), don't fit this pattern. Although caused by defects in genome maintenance via the nucleotide excision DNA repair (NER) pathway and displaying severe progeroid symptoms, CS and TTD patients appear to lack any cancer predisposition. More strikingly, genetic defects in the same NER pathway, and in some cases even within the same gene, XPD, can also give rise to disorders with greatly elevated cancer rates but without progeria (xeroderma pigmentosum). In this review, we will discuss the connection between genome maintenance, aging and cancer in light of a new mouse model of XPD disease. |
| Document Type: Review |
| Language: English |
| Reprint Address: Mitchell, JR (reprint author), Erasmus MC, Ctr Genet Med, Dept Cell Biol & Genet, Ctr Biomed Genet, POB 1738, NL-3000 DR Rotterdam, Netherlands |
Addresses:
1. Erasmus MC, Ctr Genet Med, Dept Cell Biol & Genet, Ctr Biomed Genet, NL-3000 DR Rotterdam, Netherlands
2. Univ Helsinki, Inst Biotechnol, Helsinki, Finland |
| Publisher: LANDES BIOSCIENCE, 810 SOUTH CHURCH STREET, GEORGETOWN, TX 78626 USA |
| Subject Category: Cell Biology |
| IDS Number: 117UF |
| ISSN: 1538-4101 |
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