| | |  | | | | Record from Web of Science® | | | | | | |
| Central nervous system graft-versus-host disease: report of two cases and literature review |
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| Author(s): Kamble RT (Kamble, R. T.), Chang CC (Chang, C-C), Sanchez S (Sanchez, S.), Carrum G (Carrum, G.) |
| Source: BONE MARROW TRANSPLANTATION Volume: 39 Issue: 1 Pages: 49-52 Published: JAN 2007 |
| Times Cited: 13 References: 18 |
| Abstract: Two patients with a plausible diagnosis of central nervous system graft-versus-host disease (CNS-GVHD) are described. Both presented with neurological manifestations 6 and 18 months following allogeneic transplant with hemiparesis, seizure, encephalopathy and magnetic resonance findings of hyperintense white matter lesions on T-2 weighed images. Brain biopsy in one and autopsy in the other revealed profound perivascular lymphocytic infiltrates composed predominantly of T-lymphocytes that were of donor origin. Although an unequivocal diagnosis of CNS-GVHD is difficult to establish, the transplantation community should be aware of this controversial entity. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kamble, RT (reprint author), Baylor Coll Med, Ctr Cell & Gene Therapy, 6565 Fannin St M-970, Houston, TX 77030 USA |
Addresses:
1. Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
2. Methodist Hosp, Houston, TX 77030 USA
3. Cornell Univ, Dept Pathol, Methodist Hosp, Weill Med Coll, Houston, TX USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation |
| IDS Number: 118QH |
| ISSN: 0268-3369 |
| DOI: 10.1038/sj.bmt.1705540 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |