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| Genetics of type 1 diabetes: Similarities and differences between Asian and Caucasian populations |
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| Author(s): Ikegami H (Ikegami, Hiroshi), Fujisawa T (Fujisawa, Tomomi), Kawabata Y (Kawabata, Yumiko), Noso S (Noso, Shinsuke), Ogihara T (Ogihara, Toshio) |
| Editor(s): Sanjeevi CB; Hanafusa T |
| Source: IMMUNOLOGY OF DIABETES IV: PROGRESS IN OUR UNDERSTANDING Book Series: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Volume: 1079 Pages: 51-59 Published: 2006 |
| Times Cited: 12 References: 31 |
| Abstract: Transracial studies area powerful tool for genetic association studies of multifactorial diseases, such as type 1 diabetes. We therefore studied the association of candidate genes, HLA, INS, CTLA4, PTPN22, and SUMO4, with type 1 diabetes in Asian populations in comparison with Caucasian populations. Class II HLA was strongly associated with type 1 diabetes in both Asian and Caucasian populations, but alleles associated with type 1 diabetes are different among different ethnic groups due to difference in allele distribution in general populations. INS was associated with type 1 diabetes in both Japanese and Caucasian populations, but frequency of disease-associated haplotype was markedly higher in Japanese than in Caucasian populations. CTLA4 association was reported for both type 1 diabetes and autoimmune thyroid diseases (AITD) in Caucasian populations, but the association with type 1 diabetes was concentrated in a subset of patients with AITD in Japanese. A variant (R620W) of PTPN22 was consistently associated with type 1 diabetes in Caucasian populations, but the variant was absent in Asian populations including Japanese. M55V variant of SUMO4 was significantly associated with type I diabetes in Asians, but genetic heterogeneity between Asian and Caucasian populations was suggested. These data indicate the importance of transracial studies with a large number of samples in each ethnic group in genetic dissection of type 1 diabetes. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Ikegami, H (reprint author), Kinki Univ, Sch Med, Dept Endocrinol Metab & Diabet, 377-2 Ohnohigashi, Osaka 5898511, Japan |
Addresses:
1. Kinki Univ, Sch Med, Dept Endocrinol Metab & Diabet, Osaka 5898511, Japan
2. Osaka Univ, Grad Sch Med, Dept Geriatr Med, Suita, Osaka 5650871 Japan |
| Publisher: BLACKWELL PUBLISHING, 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXEN, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: BFM87 |
| ISSN: 0077-8923 |
| ISBN: 1-57331-641-5 |
| DOI: 10.1196/annals.1375.008 |
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