| | |  | | | | Record from Web of Science® | | | | | | |
| Strategies for silencing human disease using RNA interference |
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| Author(s): Kim DH (Kim, Daniel H.), Rossi JJ (Rossi, John J.) |
| Source: NATURE REVIEWS GENETICS Volume: 8 Issue: 3 Pages: 173-184 Published: MAR 2007 |
| Times Cited: 187 References: 93 |
| Abstract: Since the first description of RNA interference (RNAi) in animals less than a decade ago, there has been rapid progress towards its use as a therapeutic modality against human diseases. Advances in our understanding of the mechanisms of RNAi and studies of RNAi in vivo indicate that RNAi-based therapies might soon provide a powerful new arsenal against pathogens and diseases for which treatment options are currently limited. Recent findings have highlighted both promise and challenges in using RNAi for therapeutic applications. Design and delivery strategies for RNAi effector molecules must be carefully considered to address safety concerns and to ensure effective, successful treatment of human diseases. |
| Document Type: Review |
| Language: English |
| Reprint Address: Rossi, JJ (reprint author), City Hope Natl Med Ctr, Beckman Res Inst, Grad Sch Biol Sci, Div Mol Biol, 1450 E Duarte Rd, Duarte, CA 91010 USA |
Addresses:
1. City Hope Natl Med Ctr, Beckman Res Inst, Grad Sch Biol Sci, Div Mol Biol, Duarte, CA 91010 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Genetics & Heredity |
| IDS Number: 137DY |
| ISSN: 1471-0056 |
| DOI: 10.1038/nrg2006 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |