| Fleshing out filaggrin phenotypes |
|
|
| Author(s): Irvine AD (Irvine, Alan D.) |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 127 Issue: 3 Pages: 504-507 Published: MAR 2007 |
| Times Cited: 52 References: 14 |
| Abstract: The association of filaggrin null alleles with eczema has been replicated in several European populations. Three large, well-conducted studies confirm this association and offer insights into the phenotypic nature of eczema associated with these alleles. Early data suggest that FLG-associated eczema may be more persistent, more likely to have palmar hyperlinearity, and more likely to be associated with asthma. These initial hints will require further confirmation in cohort studies. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Irvine, AD (reprint author), Our Ladys Hosp Sick Children, Dept Pediat Dermatol, Dublin 12, Ireland |
Addresses:
1. Our Ladys Hosp Sick Children, Dept Pediat Dermatol, Dublin 12, Ireland
2. Trinity Coll Dublin, Dept Clin Med, Dublin, Ireland |
| Publisher: NATURE PUBLISHING GROUP, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA |
| Subject Category: Dermatology |
| IDS Number: 140EL |
| ISSN: 0022-202X |
| DOI: 10.1038/sj.jid.5700695 |