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| Asymmetric T lymphocyte division in the initiation of adaptive immune responses |
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| Author(s): Chang JT (Chang, John T.), Palanivel VR (Palanivel, Vikram R.), Kinjyo I (Kinjyo, Ichiko), Schambach F (Schambach, Felix), Intlekofer AM (Intlekofer, Andrew M.), Banerjee A (Banerjee, Arnob), Longworth SA (Longworth, Sarah A.), Vinup KE (Vinup, Kristine E.), Mrass P (Mrass, Paul), Oliaro J (Oliaro, Jane), Killeen N (Killeen, Nigel), Orange JS (Orange, Jordan S.), Russell SM (Russell, Sarah M.), Weninger W (Weninger, Wolfgang), Reiner SL (Reiner, Steven L.) |
| Source: SCIENCE Volume: 315 Issue: 5819 Pages: 1687-1691 Published: MAR 23 2007 |
| Times Cited: 139 References: 40 |
| Abstract: A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity. |
| Document Type: Article |
| Language: English |
| Reprint Address: Reiner, SL (reprint author), Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA |
Addresses:
1. Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
2. Univ Penn, Dept Med, Philadelphia, PA 19104 USA
3. Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA
4. Peter MacCallum Canc Inst, Immune Signalling Lab, Melbourne, Vic 2002 Australia
5. Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
6. Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA
7. Swinburne Univ Technol, Ctr Microphoton, Fac Engn & Ind Sci, Hawthorn, Vic 3122 Australia |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 148WA |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1139393 |
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