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| Progressive multifocal leukoencephalopathy in a haploidentical stem cell transplant recipient: A clinical, neuroradiological and virological response after treatment with risperidone |
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| Author(s): Focosi D (Focosi, Daniele), Fazzi R (Fazzi, Rita), Montanaro D (Montanaro, Domenico), Emdin M (Emdin, Michele), Petrini M (Petrini, Mario) |
| Source: ANTIVIRAL RESEARCH Volume: 74 Issue: 2 Pages: 156-158 Published: MAY 2007 |
| Times Cited: 8 References: 9 |
| Abstract: JC virus (JCV) is a double-stranded DNA virus belonging to family Polyomaviridae. It causes progressive multifocal leukoencephalopathy (PML), mainly in immunosuppressed people. JCV had been shown to require the serotonin 2A receptor for host cell entry. We report a case of clinical, neuroradiological and virological response of biopsy-proven PML in a 33-year-old comatose woman after treatment with the anti-psychotic drug risperidone. Since risperidone is the tightest binding of current drugs to this receptor we think this may have blocked JCV entry in our patient, allowing her immune recovery and viral clearance. (c) 2006 Elsevier B.V. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Focosi, D (reprint author), Azienda Osped Univ Santa Chiara, Div Hematol, Via Roma 56, I-56100 Pisa, Italy |
Addresses:
1. Azienda Osped Univ Santa Chiara, Div Hematol, I-56100 Pisa, Italy
2. CNR, Dept Neuroradiol, Pisa, Italy
3. CNR, Dept Cardiovasc Med, Pisa, Italy |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Pharmacology & Pharmacy; Virology |
| IDS Number: 157MX |
| ISSN: 0166-3542 |
| DOI: 10.1016/j.antiviral.2006.10.011 |
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