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| Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 |
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| Author(s): Gudmundsson J (Gudmundsson, Julius), Sulem P (Sulem, Patrick), Manolescu A (Manolescu, Andrei), Amundadottir LT (Amundadottir, Laufey T.), Gudbjartsson D (Gudbjartsson, Daniel), Helgason A (Helgason, Agnar), Rafnar T (Rafnar, Thorunn), Bergthorsson JT (Bergthorsson, Jon T.), Agnarsson BA (Agnarsson, Bjarni A.), Baker A (Baker, Adam), Sigurdsson A (Sigurdsson, Asgeir), Benediktsdottir KR (Benediktsdottir, Kristrun R.), Jakobsdottir M (Jakobsdottir, Margret), Xu JF (Xu, Jianfeng), Blondal T (Blondal, Thorarinn), Kostic J (Kostic, Jelena), Sun JL (Sun, Jielin), Ghosh S (Ghosh, Shyamali), Stacey SN (Stacey, Simon N.), Mouy M (Mouy, Magali), Saemundsdottir J (Saemundsdottir, Jona), Backman VM (Backman, Valgerdur M.), Kristjansson K (Kristjansson, Kristleifur), Tres A (Tres, Alejandro), Partin AW (Partin, Alan W.), Albers-Akkers MT (Albers-Akkers, Marjo T.), Marcos JGI (Marcos, Javier Godino-Ivan), Walsh PC (Walsh, Patrick C.), Swinkels DW (Swinkels, Dorine W.), Navarrete S (Navarrete, Sebastian), Isaacs SD (Isaacs, Sarah D.), Aben KK (Aben, Katja K.), Graif T (Graif, Theresa), Cashy J (Cashy, John), Ruiz-Echarri M (Ruiz-Echarri, Manuel), Wiley KE (Wiley, Kathleen E.), Suarez BK (Suarez, Brian K.), Witjes JA (Witjes, J. Alfred), Frigge M (Frigge, Mike), Ober C (Ober, Carole), Jonsson E (Jonsson, Eirikur), Einarsson GV (Einarsson, Gudmundur V.), Mayordomo JI (Mayordomo, Jose I.), Kiemeney LA (Kiemeney, Lambertus A.), Isaacs WB (Isaacs, William B.), Catalona WJ (Catalona, William J.), Barkardottir RB (Barkardottir, Rosa B.), Gulcher JR (Gulcher, Jeffrey R.), Thorsteinsdottir U (Thorsteinsdottir, Unnur), Kong A (Kong, Augustine), Stefansson K (Stefansson, Kari) |
| Source: NATURE GENETICS Volume: 39 Issue: 5 Pages: 631-637 Published: MAY 2007 |
| Times Cited: 242 References: 22 |
| Abstract: Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions(1), with African American men having among the highest worldwide incidence and mortality rates(2). Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered(3), accounts for about 11% - 13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap 300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2% - 4%) susceptibility variant in individuals of European descent that happens to be very common (similar to 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis. |
| Document Type: Article |
| Language: English |
| Reprint Address: Stefansson, K (reprint author), deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland |
Addresses:
1. deCODE Genet, IS-101 Reykjavik, Iceland
2. Landspitali Univ Hosp, Dept Pathol, IS-101 Reykjavik, Iceland
3. Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC 27157 USA
4. Univ Zaragoza, Lozano Blesa Univ Hosp, Div Med Oncol, E-50009 Zaragoza, Spain
5. Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Dept Urol, Baltimore, MD 21209 USA
6. Thrombosis Serv, NL-6503 GM Nijmegen, Netherlands
7. Inst Hlth Sci, Nanotechnol Inst Aragon, Zaragoza 50009, Spain
8. Radboud Univ Nijmegen Med Ctr, Dept Clin Chem, Nijmegen, Netherlands
9. Univ Hosp, Div Radiat Oncol, Zaragoza, Spain
10. Ctr Comprehens Canc E, NL-6501 BG Nijmegen, Netherlands
11. Radboud Univ Nijmegen, Nigmegen Med Ctr, Dept Epidemiol & Biostat, NL-6500 HB Nijmegen, Netherlands
12. Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA
13. Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
14. Radboud Univ Nijmegen, Nigmegen Med Ctr, Dept Urol, NL-6500 HB Nijmegen, Netherlands
15. Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA
16. Landspital Univ Hosp, Dept Urol, IS-101 Reykjavik, Iceland
17. Radboud Univ Nijmegen, Nigmegen Med Ctr, Dept Epidemiol & Biostat, NL-6500 HB Nijmegen, Netherlands |
| Publisher: NATURE PUBLISHING GROUP, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 160VU |
| ISSN: 1061-4036 |
| DOI: 10.1038/ng1999 |
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