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| A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity |
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| Author(s): Frayling TM (Frayling, Timothy M.), Timpson NJ (Timpson, Nicholas J.), Weedon MN (Weedon, Michael N.), Zeggini E (Zeggini, Eleftheria), Freathy RM (Freathy, Rachel M.), Lindgren CM (Lindgren, Cecilia M.), Perry JRB (Perry, John R. B.), Elliott KS (Elliott, Katherine S.), Lango H (Lango, Hana), Rayner NW (Rayner, Nigel W.), Shields B (Shields, Beverley), Harries LW (Harries, Lorna W.), Barrett JC (Barrett, Jeffrey C.), Ellard S (Ellard, Sian), Groves CJ (Groves, Christopher J.), Knight B (Knight, Bridget), Patch AM (Patch, Ann-Marie), Ness AR (Ness, Andrew R.), Ebrahim S (Ebrahim, Shah), Lawlor DA (Lawlor, Debbie A.), Ring SM (Ring, Susan M.), Ben-Shlomo Y (Ben-Shlomo, Yoav), Jarvelin MR (Jarvelin, Marjo-Riitta), Sovio U (Sovio, Ulla), Bennett AJ (Bennett, Amanda J.), Melzer D (Melzer, David), Ferrucci L (Ferrucci, Luigi), Loos RJF (Loos, Ruth J. F.), Barroso I (Barroso, Ines), Wareham NJ (Wareham, Nicholas J.), Karpe F (Karpe, Fredrik), Owen KR (Owen, Katharine R.), Cardon LR (Cardon, Lon R.), Walker M (Walker, Mark), Hitman GA (Hitman, Graham A.), Palmer CNA (Palmer, Colin N. A.), Doney ASF (Doney, Alex S. F.), Morris AD (Morris, Andrew D.), Smith GD (Smith, George Davey), Hattersley AT (Hattersley, Andrew T.), McCarthy MI (McCarthy, Mark I.) |
| Source: SCIENCE Volume: 316 Issue: 5826 Pages: 889-894 Published: MAY 11 2007 |
| Times Cited: 546 References: 18 |
| Abstract: Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO ( fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hattersley, AT (reprint author), Peninsula Med Sch, Inst Biomed & Clin Sci, Magdalen Rd, Exeter, Devon England |
Addresses:
1. Peninsula Med Sch, Inst Biomed & Clin Sci, Exeter, Devon England
2. Univ Oxford, Wellcome Trust, Ctr Human Genet, Oxford, England
3. Univ Bristol, MRC, Ctr Casual Anal Translat Epidemiol, Bristol, Avon England
4. Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
5. Royal Devon & Exeter Natl Hlth Serv Fdn Trust, Mol Genet Lab, Exeter, Devon England
6. Univ Bristol, Dept Oral & Dent Sci, Sch Dent, Bristol, Avon England
7. London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1, England
8. Univ Bristol, Dept Social Med, Bristol, Avon England
9. Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England
10. Univ Oulu, Dept Publ Hlth Sci & Gen Practice, FIN-90014 Oulu, Finland
11. Peninsula Med Sch, Epidemiol & Publ Hlth Grp, Exeter, Devon England
12. NIA, Lonitudinal Studies Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA
13. Strangeways Res Labs, MRC, Epidemiol Unit, Cambridge, England
14. Sanger Inst, Metab Dis Grp, Wellcome Trust, Cambridge, England
15. Univ Newcastle, Diabet Res Grp, Sch Clin Med Sci, Newcastle Upon Tyne, Tyne & Wear England
16. Barts & London Royal London Hosp, Dept Diabet & Metab Med, London, England
17. Univ Dundee, Populat Pharmacogenet Grp, Ninewells Hosp & Med Sch, Biomed Res Ctr, Dundee DD1 9SY, Scotland
18. Univ Dundee, Ninewells Hosp & Med Sch, Diabet Res Grp, Div Med & Therapeut,Sch Med, Dundee DD1 9SY, Scotland |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 166HM |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1141634 |
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