| | |  | | | | Record from Web of Science® | | | | | | |
| IL-17 family cytokines and the expanding diversity of effector T cell lineages |
|
|
| Author(s): Weaver CT (Weaver, Casey T.), Hatton RD (Hatton, Robin D.), Mangan PR (Mangan, Paul R.), Harrington LE (Harrington, Laurie E.) |
| Source: ANNUAL REVIEW OF IMMUNOLOGY Volume: 25 Pages: 821-852 Published: 2007 |
| Times Cited: 379 References: 133 |
| Abstract: Since its conception two decades ago, the Th1-Th2 paradigm has provided a framework for understanding T cell biology and the interplay of innate and adaptive immunity. Naive T cells differentiate into effector T cells with enhanced functional potential for orchestrating pathogen clearance largely under the guidance of cytokines produced by cells of the innate immune system that have been activated by recognition of those pathogens. This secondary education of post-thymic T cells provides a mechanism for appropriately matching adaptive immunity to frontline cues of the innate immune system. Owing in part to the rapid identification of novel cytokines of the IL-17 and IL-12 families using database searches, the factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense. |
| Document Type: Review |
| Language: English |
| Reprint Address: Weaver, CT (reprint author), Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA |
Addresses:
1. Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
2. Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Immunology |
| IDS Number: 167FP |
| ISSN: 0732-0582 |
| DOI: 10.1146/annurev.immunol.25.022106.141557 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |