| | |  | | | | Record from Web of Science® | | | | | | |
| Variation in FTO contributes to childhood obesity and severe adult obesity |
|
|
| Author(s): Dina C (Dina, Christian), Meyre D (Meyre, David), Gallina S (Gallina, Sophie), Durand E (Durand, Emmanuelle), Korner A (Koerner, Antje), Jacobson P (Jacobson, Peter), Carlsson LMS (Carlsson, Lena M. S.), Kiess W (Kiess, Wieland), Vatin V (Vatin, Vincent), Lecoeur C (Lecoeur, Cecile), Delplanque J (Delplanque, Jerome), Vaillant E (Vaillant, Emmanuel), Pattou F (Pattou, Francois), Ruiz J (Ruiz, Juan), Weill J (Weill, Jacques), Levy-Marchal C (Levy-Marchal, Claire), Horber F (Horber, Fritz), Potoczna N (Potoczna, Natascha), Hercberg S (Hercberg, Serge), Le Stunff C (Le Stunff, Catherine), Bougneres P (Bougneres, Pierre), Kovacs P (Kovacs, Peter), Marre M (Marre, Michel), Balkau B (Balkau, Beverley), Cauchi S (Cauchi, Stephane), Chevre JC (Chevre, Jean-Claude), Froguel P (Froguel, Philippe) |
| Source: NATURE GENETICS Volume: 39 Issue: 6 Pages: 724-726 Published: JUN 2007 |
| Times Cited: 211 References: 12 |
| Abstract: We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at- risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses. |
| Document Type: Article |
| Language: English |
| Reprint Address: Dina, C (reprint author), Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France |
Addresses:
1. Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France
2. Univ Leipzig, Univ Hosp Children & Adolescents, D-7010 Leipzig, Germany
3. Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, S-40020 Gothenburg, Sweden
4. Univ Lille 2, INSERM, U859, F-59045 Lille, France
5. CHU Vaudois, Lausanne, Switzerland
6. Jeanne Flandre Hosp, Paediat Endocrine Unit, Lille, France
7. Hop Robert Debre, INSERM, U690, F-75019 Paris, France
8. Klin Lindberg, Winterthur, Switzerland
9. INRA, U1125, Bobigny, France
10. INSERM, U557, Bobigny, France
11. CNAM, EA3200, Paris, France
12. Univ Paris 13, Paris, France
13. CRNH, Paris, France
14. Univ Paris 05, St Vincent Paul Hosp, Dept Pediat Endocrinol, F-75005 Paris, France
15. Univ Paris 05, St Vincent Paul Hosp, INSERM U561, F-75005 Paris, France
16. Univ Leipzig, Dept Internal Med 2, D-7010 Leipzig, Germany
17. Univ Leipzig, Interdisciplinary Ctr Clin Res, D-7010 Leipzig, Germany
18. Hop Bichat Claude Bernard, AP HP, Dept Diabetol, F-75877 Paris 18, France
19. INSERM, U780, IFR69, Villejuif, France
20. Univ Paris Sud, Villejuif, France
21. Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London SW7 2AY, England |
| Publisher: NATURE PUBLISHING GROUP, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 173FO |
| ISSN: 1061-4036 |
| DOI: 10.1038/ng2048 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |