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| TMPRSS2-ERG fusion prostate cancer: An early molecular event associated with invasion |
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| Author(s): Perner S (Perner, Sven), Mosquera JM (Mosquera, Juan-Miguel), Demichelis F (Demichelis, Francesca), Hofer MD (Hofer, Matthias D.), Paris PL (Paris, Pamela L.), Simko J (Simko, Jeff), Collins C (Collins, Colin), Bismar TA (Bismar, Tarek A.), Chinnaiyan AM (Chinnaiyan, Arul M.), De Marzo AM (De Marzo, Angelo M.), Rubin MA (Rubin, Mark A.) |
| Source: AMERICAN JOURNAL OF SURGICAL PATHOLOGY Volume: 31 Issue: 6 Pages: 882-888 Published: JUN 2007 |
| Times Cited: 53 References: 27 |
| Abstract: Prostate cancer (PCA) is one of the most prevalent cancers and a major leading cause of morbidity and mortality in the Western world. The TMPRSS2-ERG fusion was recently identified as a common recurrent chromosomal aberration in this malignancy. In our study, we interrogated a broad spectrum of benign, precursor, and malignant prostatic lesions to assess the TMPRSS2-ERG fusion status using a multicolor interphase fluorescence in situ hybridization assay. Samples from hospital-based cohorts consisted of 237 clinically localized PCA, 34 hormone naive metastases, 9 hormone refractory metastases, 26 high grade prostatic intraepithelial neoplasia lesions, 15 samples of benign prostatic hyperplasia, 38 of proliferative inflammatory atrophy, and 47 of benign prostatic tissue. The TMPRSS2-ERG fusion was present in 48.5% of clinically localized PCA, 30% of hormone naive metastases, 33% of hormone refractory metastases, and in 19% of high grade prostatic intraepithelial neoplasia lesions in intermingling to cancer foci. Almost all these fusion positive cases show a homogenous distribution of the fusion pattern. In contrast, none of the other samples harbored this genetic aberration. If we consider the high incidence of PCA and the high frequency of this gene fusion, TMPRSS2-ERG is the most common genetic aberration so far described in human malignancies. Furthermore, its clinical application as a biomarker and ancillary diagnostic test is promising given its high specificity. |
| Document Type: Article |
| Language: English |
| Reprint Address: Rubin, MA (reprint author), Harvard Univ, Brigham & Womens Hosp, Dept Pathol, 221 Longwood Ave, Boston, MA 02115 USA |
Addresses:
1. Harvard Univ, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
2. Dana Farber Canc Inst, Boston, MA USA
3. Univ Ulm, Dept Pathol, D-89069 Ulm, Germany
4. ITC Irst, SRA Div, Bioinformat Grp, Povo, Trento Italy
5. Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA USA
6. McGill Univ, Fac Med, Dept Pathol & Oncol, Montreal, PQ H3A 2T5 Canada
7. Johns Hopkins Univ, Dept Pathol Urol & Oncol, Sch Med, John Hopkins Bloomberg Sch Med, Baltimore, MD USA
8. Univ Michigan, Sch Med, Comprehens Canc Ctr, Dept Pathol, Ann Arbor, MI 48109 USA
9. Univ Michigan, Sch Med, Comprehens Canc Ctr, Dept Urol, Ann Arbor, MI 48109 USA |
| Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
| Subject Category: Pathology; Surgery |
| IDS Number: 173KS |
| ISSN: 0147-5185 |
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