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| A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants |
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| Author(s): Scott LJ (Scott, Laura J.), Mohlke KL (Mohlke, Karen L.), Bonnycastle LL (Bonnycastle, Lori L.), Willer CJ (Willer, Cristen J.), Li Y (Li, Yun), Duren WL (Duren, William L.), Erdos MR (Erdos, Michael R.), Stringham HM (Stringham, Heather M.), Chines PS (Chines, Peter S.), Jackson AU (Jackson, Anne U.), Prokunina-Olsson L (Prokunina-Olsson, Ludmila), Ding CJ (Ding, Chia-Jen), Swift AJ (Swift, Amy J.), Narisu N (Narisu, Narisu), Hu T (Hu, Tianle), Pruim R (Pruim, Randall), Xiao R (Xiao, Rui), Li XY (Li, Xiao-Yi), Conneely KN (Conneely, Karen N.), Riebow NL (Riebow, Nancy L.), Sprau AG (Sprau, Andrew G.), Tong M (Tong, Maurine), White PP (White, Peggy P.), Hetrick KN (Hetrick, Kurt N.), Barnhart MW (Barnhart, Michael W.), Bark CW (Bark, Craig W.), Goldstein JL (Goldstein, Janet L.), Watkins L (Watkins, Lee), Xiang F (Xiang, Fang), Saramies J (Saramies, Jouko), Buchanan TA (Buchanan, Thomas A.), Watanabe RM (Watanabe, Richard M.), Valle TT (Valle, Timo T.), Kinnunen L (Kinnunen, Leena), Abecasis GR (Abecasis, Gonalo R.), Pugh EW (Pugh, Elizabeth W.), Doheny KF (Doheny, Kimberly F.), Bergman RN (Bergman, Richard N.), Tuomilehto J (Tuomilehto, Jaakko), Collins FS (Collins, Francis S.), Boehnke M (Boehnke, Michael) |
| Source: SCIENCE Volume: 316 Issue: 5829 Pages: 1341-1345 Published: JUN 1 2007 |
| Times Cited: 633 References: 31 |
| Abstract: Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. This brings the number of T2D loci now confidently identified to at least 10. |
| Document Type: Article |
| Language: English |
| Reprint Address: Boehnke, M (reprint author), Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA |
Addresses:
1. Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
2. Univ Michigan, Ctr State Genet, Ann Arbor, MI 48109 USA
3. Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
4. NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
5. Calvin Coll, Dept Math & Stat, Grand Rapids, MI 49546 USA
6. Johns Hopkins Univ, Sch Med, Inst Med Genet, Ctr Inherited Dis Res, Baltimore, MD 21224 USA
7. Savitaipale Hlth Ctr, Savitaipate 54800, Finland
8. Univ So Calif, Keck Sch Med, Div Endocrinol, Los Angeles, CA 90033 USA
9. Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA
10. Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA
11. Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet Unit, SF-00300 Helsinki, Finland
12. Univ Helsinki, Dept Publ Hlth, Helsinki 00014, Finland
13. S Ostrobothnia Cent Hosp, Seinajoki 60220, Finland |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 173PS |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1142382 |
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