| | |  | | | | Record from Web of Science® | | | | | | |
| Differentiation and function of Th17 T cells |
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| Author(s): Stockinger B (Stockinger, Brigitta), Veldhoen M (Veldhoen, Marc) |
| Source: CURRENT OPINION IN IMMUNOLOGY Volume: 19 Issue: 3 Pages: 281-286 Published: JUN 2007 |
| Times Cited: 150 References: 49 |
| Abstract: IL-17-producing T cells have recently been classified as a new effector T-cell subset, termed Th17, which is distinct from Th1, Th2 and Treg subsets. There has been much progress in the past year, leading to identification of the molecular mechanisms that drive differentiation of Th17 T cells. This has helped to clarify many aspects of their role in host defense as well as in autoimmunity. Nevertheless, many intriguing questions remain to be answered regarding the regulation of Th17-mediated responses as well as their interactions with the other T-cell subsets. Furthermore, the role of pathogens and pathogen-derived molecules in influencing effector T-cell polarization needs to be re-evaluated in the light of the differentiation conditions that favor Th 17 T-cell responses. |
| Document Type: Review |
| Language: English |
| Reprint Address: Stockinger, B (reprint author), MRC Natl Inst Med Res, Div Mol Immunol, Mill Hill, London NW7 1AA, England |
Addresses:
1. MRC Natl Inst Med Res, Div Mol Immunol, London NW7 1AA, England |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 173YH |
| ISSN: 0952-7915 |
| DOI: 10.1016/j.coi.2007.04.005 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |