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| Genome sequence of Aedes aegypti, a major arbovirus vector |
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| Author(s): Nene V (Nene, Vishvanath), Wortman JR (Wortman, Jennifer R.), Lawson D (Lawson, Daniel), Haas B (Haas, Brian), Kodira C (Kodira, Chinnappa), Tu ZJ (Tu, Zhijian (Jake)), Loftus B (Loftus, Brendan), Xi ZY (Xi, Zhiyong), Megy K (Megy, Karyn), Grabherr M (Grabherr, Manfred), Ren QH (Ren, Quinghu), Zdobnov EM (Zdobnov, Evgeny M.), Lobo NF (Lobo, Neil F.), Campbell KS (Campbell, Kathryn S.), Brown SE (Brown, Susan E.), Bonaldo MF (Bonaldo, Maria F.), Zhu JS (Zhu, Jingsong), Sinkins SP (Sinkins, Steven P.), Hogenkamp DG (Hogenkamp, David G.), Amedeo P (Amedeo, Paolo), Arensburger P (Arensburger, Peter), Atkinson PW (Atkinson, Peter W.), Bidwell S (Bidwell, Shelby), Biedler J (Biedler, Jim), Birney E (Birney, Ewan), Bruggner RV (Bruggner, Robert V.), Costas J (Costas, Javier), Coy MR (Coy, Monique R.), Crabtree J (Crabtree, Jonathan), Crawford M (Crawford, Matt), deBruyn B (deBruyn, Becky), DeCaprio D (DeCaprio, David), Eiglmeier K (Eiglmeier, Karin), Eisenstadt E (Eisenstadt, Eric), El-Dorry H (El-Dorry, Hamza), Gelbart WM (Gelbart, William M.), Gomes SL (Gomes, Suely L.), Hammond M (Hammond, Martin), Hannick LI (Hannick, Linda I.), Hogan JR (Hogan, James R.), Holmes MH (Holmes, Michael H.), Jaffe D (Jaffe, David), Johnston JS (Johnston, J. Spencer), Kennedy RC (Kennedy, Ryan C.), Koo H (Koo, Hean), Kravitz S (Kravitz, Saul), Kriventseva EV (Kriventseva, Evgenia V.), Kulp D (Kulp, David), LaButti K (LaButti, Kurt), Lee E (Lee, Eduardo), Li S (Li, Song), Lovin DD (Lovin, Diane D.), Mao CH (Mao, Chunhong), Mauceli E (Mauceli, Evan), Menck CFM (Menck, Carlos F. M.), Miller JR (Miller, Jason R.), Montgomery P (Montgomery, Philip), Mori A (Mori, Akio), Nascimento AL (Nascimento, Ana L.), Naveira HF (Naveira, Horacio F.), Nusbaum C (Nusbaum, Chad), O'Leary S (O'Leary, Sinead), Orvis J (Orvis, Joshua), Pertea M (Pertea, Mihaela), Quesneville H (Quesneville, Hadi), Reidenbach KR (Reidenbach, Kyanne R.), Rogers YH (Rogers, Yu-Hui), Roth CW (Roth, Charles W.), Schneider JR (Schneider, Jennifer R.), Schatz M (Schatz, Michael), Shumway M (Shumway, Martin), Stanke M (Stanke, Mario), Stinson EO (Stinson, Eric O.), Tubio JMC (Tubio, Jose M. C.), VanZee JP (VanZee, Janice P.), Verjovski-Almeida S (Verjovski-Almeida, Sergio), Werner D (Werner, Doreen), White O (White, Owen), Wyder S (Wyder, Stefan), Zeng QD (Zeng, Qiandong), Zhao Q (Zhao, Qi), Zhao YM (Zhao, Yongmei), Hill CA (Hill, Catherine A.), Raikhel AS (Raikhel, Alexander S.), Soares MB (Soares, Marcelo B.), Knudson DL (Knudson, Dennis L.), Lee NH (Lee, Norman H.), Galagan J (Galagan, James), Salzberg SL (Salzberg, Steven L.), Paulsen IT (Paulsen, Ian T.), Dimopoulos G (Dimopoulos, George), Collins FH (Collins, Frank H.), Birren B (Birren, Bruce), Fraser-Liggett CM (Fraser-Liggett, Claire M.), Severson DW (Severson, David W.) |
| Source: SCIENCE Volume: 316 Issue: 5832 Pages: 1718-1723 Published: JUN 22 2007 |
| Times Cited: 128 References: 37 |
| Abstract: We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at similar to 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of similar to 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of similar to 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species. |
| Document Type: Article |
| Language: English |
| Reprint Address: Nene, V (reprint author), Inst Genome Res, 9712 Med Ctr Dr, Rockville, MD 20850 USA |
Addresses:
1. Inst Genome Res, Rockville, MD 20850 USA
2. European Bioinformat Inst EMBL EBI, Hinxton CB10 1SD, Cambs England
3. MIT, Broad Inst, Cambridge, MA 02141 USA
4. Harvard Univ, Broad Inst, Cambridge, MA 02141 USA
5. Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA
6. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA
7. Univ Geneva, Sch Med, CH-1211 Geneva, Switzerland
8. Swiss Inst Bioinformat, CH-1211 Geneva, Switzerland
9. Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England
10. Univ Notre Dame, Notre Dame, IN 46556 USA
11. Harvard Univ, Cambridge, MA 02138 USA
12. Colorado State Univ, Coll Agr Sci, Ft Collins, CO 80523 USA
13. Northwestern Univ, Chicago, IL 60614 USA
14. Univ Calif Riverside, Riverside, CA 92521 USA
15. Univ Oxford, Oxford OX1 3PS, England
16. Purdue Univ, W Lafayette, IN 47907 USA
17. Hosp Clin Univ Santiago, Fdn Publ Galega Med Xenom, Ctr Nacl Genotipado, E-15706 Santiago, Spain
18. Inst Pasteur, F-75724 Paris, France
19. Univ Sao Paulo, Inst Quim, BR-05508900 Sao Paulo, Brazil
20. Texas A&M Univ, College Stn, TX 77843 USA
21. Joint Technol Ctr, Rockville, MD 20850 USA
22. Univ Massachusetts, Amherst, MA 01003 USA
23. Univ Sao Paulo, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil
24. Inst Butantan, BR-05503900 Sao Paulo, Brazil
25. Univ Coruna, La Coruna 15001, Spain
26. Univ Paris Diderot, CNRS, Inst Jacques Monod, F-75252 Paris, France
27. Univ Paris 06, F-75252 Paris, France
28. Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
29. Univ Gottingen, D-37077 Gottingen, Germany
30. Complexo Hosp Univ Santiago, Santiago De Compostela 15706, Spain |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 180XE |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1138878 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |