| | |  | | | | Record from Web of Science® | | | | | | |
| Patched1 regulates Hedgehog signaling at the primary cilium |
|
|
| Author(s): Rohatgi R (Rohatgi, Rajat), Milenkovic L (Milenkovic, Ljiljana), Scott MP (Scott, Matthew P.) |
| Source: SCIENCE Volume: 317 Issue: 5836 Pages: 372-376 Published: JUL 20 2007 |
| Times Cited: 128 References: 16 |
| Abstract: Primary cilia are essential for transduction of the Hedgehog (Hh) signal in mammals. We investigated the role of primary cilia in regulation of Patched1 (Ptc1), the receptor for Sonic Hedgehog (Shh). Ptc1 localized to cilia and inhibited Smoothened (Smo) by preventing its accumulation within cilia. When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function. |
| Document Type: Article |
| Language: English |
| Reprint Address: Scott, MP (reprint author), Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA |
Addresses:
1. Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA
2. Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
3. Stanford Univ, Sch Med, Dept Bioengn, Stanford, CA 94305 USA
4. Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA
5. Stanford Univ, Sch Med, Dept Oncol, Stanford, CA 94305 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 191RR |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1139740 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |