| HEPTAD REPEAT SEQUENCES ARE LOCATED ADJACENT TO HYDROPHOBIC REGIONS IN SEVERAL TYPES OF VIRUS FUSION GLYCOPROTEINS |
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| Author(s): CHAMBERS P, PRINGLE CR, EASTON AJ |
| Source: JOURNAL OF GENERAL VIROLOGY Volume: 71 Pages: 3075-3080 Part: Part 12 Published: DEC 1990 |
| Times Cited: 186 References: 52 |
| Abstract: Extensive regions of heptad repeat units consistent with an alpha-helical coiled coil conformation are located adjacent to hydrophobic, potentially fusion-related regions in the amino acid sequences of paramyxovirus fusion and retrovirus envelope glycoproteins. Similar arrangements of hydrophobic peptides and heptad repeat units exist in coronavirus peplomer proteins and influenza virus haemagglutinins. This suggests that there may be similarities in the structures of these proteins and in the functions of the hydrophobic fusion-related regions during virus entry. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV WARWICK, DEPT BIOL SCI, COVENTRY CV4 7AL, W MIDLANDS ENGLAND |
| Publisher: SOC GENERAL MICROBIOLOGY, HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS |
| Subject Category: Biotechnology & Applied Microbiology; Virology |
| IDS Number: EP009 |
| ISSN: 0022-1317 |