| | |  | | | | Record from Web of Science® | | | | | | |
| CATHEPSIN-D IN BREAST-CANCER - FROM MOLECULAR AND CELLULAR BIOLOGY TO CLINICAL-APPLICATIONS |
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| Author(s): ROCHEFORT H, CAPONY F, GARCIA M |
| Source: CANCER CELLS-A MONTHLY REVIEW Volume: 2 Issue: 12 Pages: 383-388 Published: DEC 1990 |
| Times Cited: 67 References: 42 |
| Abstract: Cathepsin D is a ubiquitously expressed lysosomal protease. Initially synthesized as an inactive precursor of 52 kD (pro-cathepsin D), the enzyme is subsequently converted to its active forms by proteolytic processing. Breast cancer cells, unlike normal cells, secrete high levels of pro-cathepsin D; this abnormal secretion is due to both overexpression of the gene and altered processing of the protein. Recent transfection experiments indicate that overexpression of cathepsin D can increase the metastatic potential of tumor cells in nude mice. This study complements clinical studies, which have shown that high cathepsin D concentrations in the cytosol of primary breast cancers may be predictive of subsequent metastasis, particularly for patients with axillary node-negative tumors. These results, and the potential mechanisms by which cathepsin D may promote metastasis, are considered here. |
| Document Type: Review |
| Language: English |
| Reprint Address: ROCHEFORT, H (reprint author), UNIV MONTPELLIER 1, UNITE HORMONES & CANC, INSERM, U148, F-34090 MONTPELLIER, FRANCE |
| Publisher: COLD SPRING HARBOR LAB PRESS, 1 BUNGTOWN RD, PLAINVIEW, NY 11724 |
| Subject Category: Oncology; Medicine, Research & Experimental |
| IDS Number: EP819 |
| ISSN: 1042-2196 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |