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| FLAVONOIDS INHIBIT THE EXPRESSION OF HEAT-SHOCK PROTEINS |
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| Author(s): HOSOKAWA N, HIRAYOSHI K, NAKAI A, HOSOKAWA Y, MARUI N, YOSHIDA M, SAKAI T, NISHINO H, AOIKE A, KAWAI K, NAGATA K |
| Source: CELL STRUCTURE AND FUNCTION Volume: 15 Issue: 6 Pages: 393-401 Published: DEC 1990 |
| Times Cited: 117 References: 40 |
| Abstract: Cells exposed to several forms of stress, such as heat shock, transiently synthesize a group of proteins called heat shock proteins (hsps). Although many stressors other than heat shock are known to induce hsps, inhibitors of hsp expression have never been reported. Here we show that quercetin and several other flavonoids inhibit the synthesis of hsps induced by heat shock in two human cell lines, Hela cells and COLO320 DM cells. Quercetin inhibited the induction of hsp 70 at the level of mRNA accumulation. This is the first report to describe the inhibition of hsp expression by reagents. |
| Document Type: Article |
| Language: English |
Addresses:
1. KYOTO UNIV, CHEST DIS RES INST, DEPT CELL BIOL, SAKYO KU, KYOTO 606, JAPAN
2. KYOTO PREFECTURAL UNIV MED, DEPT PATHOL, KAMIKYO KU, KYOTO 602, JAPAN
3. KYOTO PREFECTURAL UNIV MED, DEPT PREVENT MED, KAMIKYO KU, KYOTO 602, JAPAN
4. KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIKYO KU, KYOTO 602, JAPAN |
| Publisher: JAPAN SOC CELL BIOLOGY, SHIMOTACHIURI OGAWA-HIGASHI, KAMIKYOKU KYOTO 602, JAPAN |
| Subject Category: Cell Biology |
| IDS Number: EW333 |
| ISSN: 0386-7196 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |