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| A GENE FROM THE REGION OF THE HUMAN X-INACTIVATION CENTER IS EXPRESSED EXCLUSIVELY FROM THE INACTIVE X-CHROMOSOME |
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| Author(s): BROWN CJ, BALLABIO A, RUPERT JL, LAFRENIERE RG, GROMPE M, TONLORENZI R, WILLARD HF |
| Source: NATURE Volume: 349 Issue: 6304 Pages: 38-44 Published: JAN 3 1991 |
| Times Cited: 469 References: 41 |
| Abstract: X-chromosome inactivation results in the cis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern-transcript are detected only from the inactive X chromosome (X(i)) and not from the active X chromosome (X(a)). This gene, called XIST (for X(i)-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation. |
| Document Type: Article |
| Language: English |
Addresses:
1. STANFORD UNIV, MED CTR, SCH MED, DEPT GENET, STANFORD, CA 94305 USA
2. BAYLOR UNIV, INST MOLEC GENET, HOUSTON, TX 77030 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: EQ601 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |