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THE GTPASE SUPERFAMILY - CONSERVED STRUCTURE AND MOLECULAR MECHANISM
Author(s): BOURNE HR, SANDERS DA, MCCORMICK F
Source: NATURE    Volume: 349    Issue: 6305    Pages: 117-127    Published: JAN 10 1991  
Times Cited: 2,325     References: 150     
Abstract: GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases - crystal structures, biochemical properties, or results of molecular genetic experiments - support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.
Document Type: Review
Language: English
Reprint Address: BOURNE, HR (reprint author), UNIV CALIF SAN FRANCISCO, DEPT PHARMACOL, SAN FRANCISCO, CA 94110 USA
Addresses:
1. UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94110 USA
2. UNIV CALIF SAN FRANCISCO, CARDIOVASC RES INST, SAN FRANCISCO, CA 94110 USA
3. CETUS CORP, DEPT MOLEC BIOL, EMERYVILLE, CA 94608 USA
Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF
Subject Category: Multidisciplinary Sciences
IDS Number: ER418
ISSN: 0028-0836
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