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| GENOMIC IMPRINTING IN MAMMALIAN DEVELOPMENT - A PARENTAL TUG-OF-WAR |
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| Author(s): MOORE T, HAIG D |
| Source: TRENDS IN GENETICS Volume: 7 Issue: 2 Pages: 45-49 Published: FEB 1991 |
| Times Cited: 463 References: 37 |
| Abstract: Genomic imprinting in mammals is increasingly being implicated in developmental and pathological processes, but without a clear understanding of its function in normal development. We believe that imprinting has evolved in mammals because of the conflicting interests of maternal and paternal genes in relation to the transfer of nutrients from the mother to her offspring. We present an hypothesis that accounts for many of the observed effects of imprinting in mammals and relates them to similar observations in plants. This hypothesis has implications for studies of X-chromosome inactivation and a range of human diseases. |
| Document Type: Article |
| Language: English |
| Reprint Address: MOORE, T (reprint author), ST GEORGE HOSP, SCH MED, EXPTL EMBRYOL & TERATOL UNIT, CRANMER TERRACE, LONDON SW17 0RE, ENGLAND |
Addresses:
1. UNIV OXFORD, DEPT PLANT SCI, OXFORD OX1 3RA, ENGLAND |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Genetics & Heredity |
| IDS Number: ET668 |
| ISSN: 0168-9525 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |