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| NERVE GROWTH-FACTOR STIMULATES PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA IN PC12 CELLS |
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| Author(s): KIM UH, FINK D, KIM HS, PARK DJ, CONTRERAS ML, GUROFF G, RHEE SG |
| Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 266 Issue: 3 Pages: 1359-1362 Published: JAN 25 1991 |
| Times Cited: 156 References: 40 |
| Abstract: PC12 cells contain at least three immunologically distinct phospholipase C (PLC) isozymes, PLC-beta, PLC-gamma, and PLC-delta. Treatment of PC12 cells with nerve growth factor (NGF) leads to an increase in the phosphorylation of PLC-gamma, but not of PLC-beta or PLC-delta. This increase can be seen in as little as 1 minute. The increased phosphorylation occurs on both serine and tyrosine residues, with the major increase being in the former. This result suggests the possibility that the NGF-dependent increase in phosphoinositide hydrolysis in PC12 cells is due to selective phosphorylation of PLC-gamma by serine and tyrosine protein kinases associated with the NGF receptor. |
| Document Type: Note |
| Language: English |
Addresses:
1. NHLBI, ZENTRUM BIOCHEM, SIGNAL TRANSDUCT SECT, BETHESDA, MD 20892 USA
2. NICHHD, GROWTH FACTORS SECT, BETHESDA, MD 20892 USA |
| Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: EU497 |
| ISSN: 0021-9258 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |