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| T-CELL RECEPTOR PEPTIDE THERAPY TRIGGERS AUTOREGULATION OF EXPERIMENTAL ENCEPHALOMYELITIS |
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| Author(s): OFFNER H, HASHIM GA, VANDENBARK AA |
| Source: SCIENCE Volume: 251 Issue: 4992 Pages: 430-432 Published: JAN 25 1991 |
| Times Cited: 225 References: 28 |
| Abstract: Encephalitogenic T cells specific for myelin basic protein share common V-beta-8 peptide sequences in their T cell receptor (TCR) that can induce autoregulatory T cells and antibodies that prevent clinical signs of experimental autoimmune encephalomyelitis (EAE). It is not known, however, if TCR peptides can treat established disease. To test its therapeutic value, TCR-V-beta-8-39-59 peptide was injected into rats with clinical signs of EAE. This treatment reduced disease severity and speeded recovery, apparently by boosting anti-V-beta-8 T cells and antibodies raised naturally in response to encephalitogenic V-beta-8+ T cells. These results demonstrate that synthetic TCR be used therapeutically, and implicate the TCR-V-beta-8-39-59 sequence as a natural idiotope involved in EAE recovery. Similarly, human TCR peptides may be effective in enhancing natural regulation of autoreactive T cells that share common V genes. |
| Document Type: Article |
| Language: English |
| Reprint Address: OFFNER, H (reprint author), VET ADM MED CTR, PORTLAND, OR 97201 USA |
Addresses:
1. ST LUKES ROOSEVELT HOSP, DEPT MICROBIOL & SURG, NEW YORK, NY 10025 USA
2. OREGON HLTH SCI UNIV, DEPT NEUROL, PORTLAND, OR 97201 USA
3. OREGON HLTH SCI UNIV, DEPT MICROBIOL & IMMUNOL AAV, PORTLAND, OR 97201 USA
4. COLUMBIA UNIV, NEW YORK, NY 10027 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: EU504 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |