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| COFACTORS IN MALE-FEMALE SEXUAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 |
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| Author(s): PLUMMER FA, SIMONSEN JN, CAMERON DW, NDINYAACHOLA JO, KREISS JK, GAKINYA MN, WAIYAKI P, CHEANG M, PIOT P, RONALD AR, NGUGI EN |
| Source: JOURNAL OF INFECTIOUS DISEASES Volume: 163 Issue: 2 Pages: 233-239 Published: FEB 1991 |
| Times Cited: 517 References: 24 |
| Abstract: In a study of human immunodeficiency virus type 1 (HIV-1)-uninfected African prostitutes, 83 (67%) of 124 seroconverted to HIV-1. Oral contraceptive use (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.1-8.6; P < .03), genital ulcers (mean annual episodes, 1.32 +/- 0.55 in seroconverting women vs. 0.48 +/- 0.21 in seronegative women; P < .02) and Chlamydia trachomatis infections (OR, 3.6; CI, 1.3-11.0; P < .02) were associated with increased risk of HIV-1 infection. Condom use reduced the risk of HIV-1 infection (OR, 0.11; CI, 0.05-0.27; P < .0001). Stepwise logistic regression analysis confirmed independent associations between HIV-1 infection and oral contraceptive use, condom use, genital ulcers, and C. trachomatis. The presence of other sexually transmitted diseases may in part explain the heterosexual HIV-1 epidemic in Africa and may represent important targets for intervention to control HIV-1 infection. |
| Document Type: Article |
| Language: English |
| Reprint Address: PLUMMER, FA (reprint author), UNIV MANITOBA, DEPT MED MICROBIOL, RM 523, BASIC MED SCI BLDG, 730 WILLIAM AVE, WINNIPEG R3E 0W3, MANITOBA CANADA |
Addresses:
1. UNIV NAIROBI, KENYA MED RES INST, NAIROBI, KENYA
2. MINIST HLTH, NAIROBI, KENYA
3. INST TROP MED PRINCE LEOPOLD, B-2000 ANTWERP, BELGIUM
4. UNIV WASHINGTON, SEATTLE, WA 98195 USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Infectious Diseases |
| IDS Number: EU573 |
| ISSN: 0022-1899 |
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