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| THE MYOD GENE FAMILY - NODAL POINT DURING SPECIFICATION OF THE MUSCLE-CELL LINEAGE |
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| Author(s): WEINTRAUB H, DAVIS R, TAPSCOTT S, THAYER M, KRAUSE M, BENEZRA R, BLACKWELL TK, TURNER D, RUPP R, HOLLENBERG S, ZHUANG Y, LASSAR A |
| Source: SCIENCE Volume: 251 Issue: 4995 Pages: 761-766 Published: FEB 15 1991 |
| Times Cited: 1,222 References: 86 |
| Abstract: The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis. |
| Document Type: Article |
| Language: English |
| Reprint Address: WEINTRAUB, H (reprint author), FRED HUTCHINSON CANC RES CTR, HOWARD HUGHES MED INST, 1124 COLUMBIA ST, SEATTLE, WA 98104 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: EX575 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |