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PHOSPHATIDYLINOSITOL MEMBRANE ANCHORS AND T-CELL ACTIVATION
Author(s): ROBINSON PJ
Source: IMMUNOLOGY TODAY    Volume: 12    Issue: 1    Pages: 35-41    Published: JAN 1991  
Times Cited: 282     References: 55     
Abstract: A number of lymphocyte proteins are attached to the cell membrane via glycophosphatidylinositol-anchoring domains. Antibodies specific for several of these proteins are potent mitogens for T cells. In this article, Peter Robinson reviews recent evidence for the involvement of these membrane anchors in cell signalling events and discusses their possible significance in providing antigen-independent costimulatory signals to lymphoid cells.
Document Type: Article
Language: English
Reprint Address: ROBINSON, PJ (reprint author), CLIN RES CTR, TRANSPLANTAT BIOL SECT, WATFORD RD, HARROW HA1 3UJ, MIDDX ENGLAND
Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB
Subject Category: Immunology
IDS Number: EY314
ISSN: 0167-5699
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