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| ELECTROCHEMOTHERAPY POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY LOCAL ELECTRIC PULSES |
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| Author(s): MIR LM, ORLOWSKI S, BELEHRADEK J, PAOLETTI C |
| Source: EUROPEAN JOURNAL OF CANCER Volume: 27 Issue: 1 Pages: 68-72 Published: 1991 |
| Times Cited: 232 References: 16 |
| Abstract: In cell culture the cytotoxicity of some anticancer drugs, especially bleomycin, can be greatly enhanced by exposing cells to non-cytotoxic electric pulses. Nude or conventional mice bearing subcutaneous transplanted tumours were treated with intramuscular doses of bleomycin followed by local delivery of electric pulses similar to those used in vitro. Tumours were reduced and even eradicated after this electrochemotherapy. Thus the antitumour effects of bleomycin in mice can be considerably potentiated by local electric pulses. |
| Document Type: Article |
| Language: English |
| Reprint Address: MIR, LM (reprint author), INST GUSTAVE ROUSSY, BIOCHIM ENZYMOL LAB, CNRS, URA 158, INSERM, U140, F-94805 VILLEJUIF, FRANCE |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB |
| Subject Category: Oncology |
| IDS Number: FB045 |
| ISSN: 0959-8049 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |