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| THE CYCLIC-AMP PHOSPHODIESTERASE ENCODED BY THE DROSOPHILA DUNCE GENE IS CONCENTRATED IN THE MUSHROOM BODY NEUROPIL |
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| Author(s): NIGHORN A, HEALY MJ, DAVIS RL |
| Source: NEURON Volume: 6 Issue: 3 Pages: 455-467 Published: MAR 1991 |
| Times Cited: 176 References: 39 |
| Abstract: Drosophila dunce (dnc) flies are defective in learning and memory as a result of lesions in the gene that codes for a cAMP-specific phosphodiesterase (PDE). Antibodies to the dnc PDE showed that the most intensely stained regions in the adult brain were the mushroom body neurophil-areas previously implicated in learning and memory. In situ hybridization demonstrated that dnc RNA was enriched in the mushroom body perikarya. The mushroom bodies of third instar larval brains were also stained intensely by the antibody, suggesting that the dnc PDE plays an important role in these neurons throughout their development. The role of the dnc PDE in mushroom body physiology is discussed, and a circuit model describing a possible role of the mushroom bodies in mediating olfactory learning and memory is presented. |
| Document Type: Article |
| Language: English |
| Reprint Address: NIGHORN, A (reprint author), BAYLOR UNIV, DEPT CELL BIOL, HOUSTON, TX 77030 USA |
Addresses:
1. CSIRO, DIV ENTOMOL, CANBERRA, ACT 2601 AUSTRALIA
2. BAYLOR UNIV, DIV NEUROSCI, HOUSTON, TX 77030 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: FC470 |
| ISSN: 0896-6273 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |