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| KILLING OF PATHOGENS ASSOCIATED WITH CHRONIC GRANULOMATOUS-DISEASE BY THE NONOXIDATIVE MICROBICIDAL MECHANISMS OF HUMAN NEUTROPHILS |
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| Author(s): ODELL EW, SEGAL AW |
| Source: JOURNAL OF MEDICAL MICROBIOLOGY Volume: 34 Issue: 3 Pages: 129-135 Published: MAR 1991 |
| Times Cited: 23 References: 55 |
| Abstract: The susceptibility of opportunist pathogens associated with chronic granulomatous disease (CGD) to the non-oxidative killing mechanisms of neutrophils has been assessed by incubation in human neutrophil primary granule lysate. The dose and pH-dependency of killing of Aspergillus fumigatus, Candida albicans, Escherichia coli, Nocardia asteroides, Serratia marcescens and Staphylococcus aureus differed markedly and may partly explain their virulence in CGD, in which oxygen-dependent killing mechanisms are defective. At the acid pH in CGD neutrophil phagosomes S. aureus, Ser. marcescens, N. asteroides and A. fumigatus spores were highly resistant but C. albicans, a less frequent pathogen in patients with CGD, was much more susceptible. |
| Document Type: Article |
| Language: English |
| Reprint Address: ODELL, EW (reprint author), UNITED MED & DENT SCH GUYS & ST THOMAS HOSP, GUYS HOSP, DEPT ORAL MED & PATHOL, LONDON BRIDGE, LONDON SE1 9RT, ENGLAND |
Addresses:
1. UNIV LONDON UNIV COLL, RAYNE INST, DEPT MED, LONDON WC1E 6JJ, ENGLAND |
| Publisher: CHAPMAN HALL LTD, 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN |
| Subject Category: Microbiology |
| IDS Number: FD315 |
| ISSN: 0022-2615 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |