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| CD8+ CELL ANTI-HIV ACTIVITY CORRELATES WITH THE CLINICAL STATE OF THE INFECTED INDIVIDUAL |
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| Author(s): MACKEWICZ CE, ORTEGA HW, LEVY JA |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 87 Issue: 4 Pages: 1462-1466 Published: APR 1991 |
| Times Cited: 276 References: 33 |
| Abstract: The extent of antiviral activity exhibited in vitro by CD8+ lymphocytes from individuals infected by HIV-1 correlates significantly with their clinical status. CD8+ lymphocytes from asymptomatic subjects were found to inhibit HIV-1 replication by 90% or greater at effector/target (E/T) ratios ranging from as low as 0.05 to 0.25. CD8+ cells from 17 of 19 (89%) of these subjects suppressed replication at an E/T ratio of 0.10 or less. CD8+ lymphocytes from symptomatic patients (non-AIDS) inhibited HIV-1 replication at E/T ratios ranging from 0.05 to 1.0, and CD8+ cells from 8 of 13 (62%) required ratios > 0.10. As a group, patients with AIDS exhibited the lowest degree of anti-HIV activity with their CD8+ lymphocytes. The effective range of E/T ratios from AIDS patients was 0.10-2.0, and 9 of 10 (90%) required E/T ratios > 0.25. This anti-HIV activity exhibited by CD8+ cells also correlated significantly with the subject's peripheral blood CD4+ cell count. The relative extent of CD8+ cell anti-HIV-1 activity was not found dependent on variations in the CD4+ target cells and viruses used. These findings suggest that the decreased CD8+ cell antiviral activity is related to progression to disease in HIV-infected individuals. |
| Document Type: Note |
| Language: English |
Addresses:
1. UNIV CALIF SAN FRANCISCO, SCH MED, CANC RES INST, DEPT MED, SAN FRANCISCO, CA 94143 USA |
| Publisher: ROCKEFELLER UNIV PRESS, 222 E 70TH STREET, NEW YORK, NY 10021 |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: FE722 |
| ISSN: 0021-9738 |
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