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| SELECTIVE ACTIVATION OF THE B-NATRIURETIC PEPTIDE RECEPTOR BY C-TYPE NATRIURETIC PEPTIDE (CNP) |
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| Author(s): KOLLER KJ, LOWE DG, BENNETT GL, MINAMINO N, KANGAWA K, MATSUO H, GOEDDEL DV |
| Source: SCIENCE Volume: 252 Issue: 5002 Pages: 120-123 Published: APR 5 1991 |
| Times Cited: 611 References: 31 |
| Abstract: The natriuretic peptides are hormones that can stimulate natriuretic, diuretic, and vasorelaxant activity in vivo, presumably through the activation of two known cell surface receptor guanylyl cyclases (ANPR-A and ANPR-B). Although atrial natriuretic peptide (ANP) and, to a lesser extent, brain natriuretic peptide (BNP) are efficient activators of the ANPR-A guanylyl cyclase, neither hormone can significantly stimulate ANPR-B. A member of this hormone family, C-type natriuretic peptide (CNP), potently and selectively activated the human ANPR-B guanylyl cyclase. CNP does not increase guanosine 3',5'-monophosphate accumulation in cells expressing human ANPR-A. The affinity of CNP for ANPR-B is 50- or 500-fold higher than ANP or BNP, respectively. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system. |
| Document Type: Article |
| Language: English |
| Reprint Address: KOLLER, KJ (reprint author), GENENTECH INC, DEPT MOLEC BIOL, S SAN FRANCISCO, CA 94080 USA |
Addresses:
1. GENENTECH INC, DEPT IMMUNOL RES & ASSAY TECHNOL, S SAN FRANCISCO, CA 94080 USA
2. NATL CARDIOVASC CTR, RES INST, SUITA, OSAKA 565 JAPAN
3. MIYAZAKI MED COLL, DEPT BIOCHEM, MIYAZAKI 88916, JAPAN |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: FE952 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |