| | |  | | | | Record from Web of Science® | | | | | | |
| THE DENDRITIC CELL SYSTEM AND ITS ROLE IN IMMUNOGENICITY |
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| Author(s): STEINMAN RM |
| Source: ANNUAL REVIEW OF IMMUNOLOGY Volume: 9 Pages: 271-296 Published: 1991 |
| Times Cited: 3,424 References: 136 |
| Abstract: Dendritic cells are a system of antigen presenting cells that function to initiate several immune responses such as the sensitization of MHC-restricted T cells, the rejection of organ transplants, and the formation of T-dependent antibodies. Dendritic cells are found in many nonlymphoid tissues but can migrate via the afferent lymph or the blood stream to the T-dependent areas of lymphoid organs. In skin, the immunostimulatory function of dendritic cells is enhanced by cytokines, especially GM-CSF. After foreign proteins are administered in situ, dendritic cells are a principal reservoir of immunogen. In vitro studies indicate that dendritic cells only process proteins for a short period of time, when the rate of synthesis of MHC products and content of acidic endocytic vesicles are high. Antigen processing is selectively dampened after a day in culture, but the capacity to stimulate responses to surface bound peptides and mitogens remains strong. Dendritic cells are motile, and efficiently cluster and activate T cells that are specific for stimuli on the cell surface. High levels of MHC class-I and -II products and several adhesins, such as ICAM-1 and LFA-3, likely contribute to these functions. Therefore dendritic cells are specialized to mediate several physiologic components of immunogenicity such as the acquisition of antigens in tissues, the migration to lymphoid organs, and the identification and activation of antigen-specific T cells. The function of these presenting cells in immunologic tolerance is just beginning to be studied. |
| Document Type: Review |
| Language: English |
| Reprint Address: STEINMAN, RM (reprint author), ROCKEFELLER UNIV, CELLULAR PHYSIOL & IMMUNOL LAB, NEW YORK, NY 10021 USA |
Addresses:
1. ROCKEFELLER UNIV, IRVINGTON INST, NEW YORK, NY 10021 USA |
| Publisher: ANNUAL REVIEWS INC, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 |
| Subject Category: Immunology |
| IDS Number: FF998 |
| ISSN: 0732-0582 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |