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| MOLECULAR ABNORMALITY OF TAMM-HORSFALL GLYCOPROTEIN IN CALCIUM-OXALATE NEPHROLITHIASIS |
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| Author(s): HESS B, NAKAGAWA Y, PARKS JH, COE FL |
| Source: AMERICAN JOURNAL OF PHYSIOLOGY Volume: 260 Issue: 4 Pages: F569-F578 Part: Part 2 Published: APR 1991 |
| Times Cited: 76 References: 31 |
| Abstract: Tamm-Horsfall glycoprotein (THP) inhibits self-aggregation of calcium oxalate monohydrate (COM) crystals and may therefore be part of the natural defenses against deposition of COM in the kidney in the form of stones or nephrocalcinosis. We have studied THP from six patients with severe nephrolithiasis and have found that their THP inhibits COM self-aggregation less than normal THP under conditions of NaCl and THP concentration and pH similar to those of human urine. The reason for the reduced inhibition of COM crystal aggregation seems to be an enhanced self-aggregation of patient THP, which removes it from effective interactions with the COM crystals. In one family, the father and the oldest son both excreted THP that behaved abnormally and in similar ways, whereas THP from the other son and from the wife behaved normally. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CHICAGO, PRITZKER SCH MED, NEPHROL PROGRAM, NEPHROL SECT, BOX 28, 5841 S MARYLAND AVE, CHICAGO, IL 60637 USA
2. UNIV CHICAGO, PRITZKER SCH MED, DEPT BIOCHEM & MOLEC BIOL, CHICAGO, IL 60637 USA |
| Publisher: AMER PHYSIOLOGICAL SOC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Physiology |
| IDS Number: FG542 |
| ISSN: 0002-9513 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |