| | |  | | | | Record from Web of Science® | | | | | | |
| CELL DYSFUNCTION AND DEPLETION IN AIDS - THE PROGRAMMED CELL-DEATH HYPOTHESIS |
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| Author(s): AMEISEN JC, CAPRON A |
| Source: IMMUNOLOGY TODAY Volume: 12 Issue: 4 Pages: 102-105 Published: APR 1991 |
| Times Cited: 464 References: 50 |
| Abstract: Normal immature thymocytes respond to activation by undergoing programmed cell death (apoptosis), a physiological deletion mechanism involved in the selection of the T-cell repertoire. In this article, Jean Claude Ameisen and Andre Capron suggest that inappropriate induction of a form of programmed T-cell death could account for both qualitative and quantitative helper T-cell defects of HIV-infected patients. A model of AIDS pathogenesis is presented that may explain several features of HIV infection, including evolution of the disease and the development of defects in nonimmunological organs. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: AMEISEN, JC (reprint author), INST PASTEUR, CNRS, UNITE 624, INSERM, U167, CTR IMMUNOL & BIOL PARASITAIRE, F-59019 LILLE, FRANCE |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Immunology |
| IDS Number: FH078 |
| ISSN: 0167-5699 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |