| | |  | | | | Record from Web of Science® | | | | | | |
| AUTOIMMUNITY, MICROBIAL IMMUNITY AND THE IMMUNOLOGICAL HOMUNCULUS |
|
|
| Author(s): COHEN IR, YOUNG DB |
| Source: IMMUNOLOGY TODAY Volume: 12 Issue: 4 Pages: 105-110 Published: APR 1991 |
| Times Cited: 377 References: 75 |
| Abstract: Clonal deletion and anergy are believed by many immunologists to be the fundamental mechanisms responsible for self tolerance. Nevertheless, as Irun Cohen and Douglas Young point out, such notions of nonreactivity cannot explain certain key features of immune behaviour: the immunological dominance of microbial antigens that mimic self, the uniformity of autoimmune diseases and the prevalence of natural autoimmunity among the healthy. The theory of the immunological homunculus is presented here as a unifying principle. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: COHEN, IR (reprint author), WEIZMANN INST SCI, DEPT CELL BIOL, IL-76100 REHOVOT, ISRAEL |
Addresses:
1. HAMMERSMITH HOSP, ROYAL POSTGRAD MED SCH, MRC, TB & RELATED INFECT UNIT, LONDON W12 0HS, ENGLAND |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Immunology |
| IDS Number: FH078 |
| ISSN: 0167-5699 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |