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| LONG-TERM HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION IN ASYMPTOMATIC HOMOSEXUAL AND BISEXUAL MEN WITH NORMAL CD4+ LYMPHOCYTE COUNTS - IMMUNOLOGICAL AND VIROLOGICAL CHARACTERISTICS |
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| Author(s): LIFSON AR, BUCHBINDER SP, SHEPPARD HW, MAWLE AC, WILBER JC, STANLEY M, HART CE, HESSOL NA, HOLMBERG SD |
| Source: JOURNAL OF INFECTIOUS DISEASES Volume: 163 Issue: 5 Pages: 959-965 Published: MAY 1991 |
| Times Cited: 134 References: 56 |
| Abstract: From a prospective cohort study, 24 asymptomatic men were identified who had been antibody positive for human immunodeficiency virus (HIV) for at least 5 years (median = 9.1) with CD4+ lymphocyte counts greater-than-or-equal-to 400 cells/mm3. Of these "nonprogressors," 23 (96%) had evidence of HIV infection by either HIV culture or the polymerase chain reaction (PCR) for HIV DNA, although only 1 (4%) had a positive assay for HIV RNA (by PCR) and no one was positive for p24 antigen. Compared with 24 antibody-negative men and 14 men with AIDS, nonprogressors had higher CD8+ counts and lower natural killer cell activity. Nonprogressors had higher beta-2-microglobulin levels than did seronegative controls, suggesting some degree of immune system activation. Compared with men with AIDS, nonprogressors seemed to have a stronger antibody response to six different HIV-related proteins but did not differ significantly in neutralizing antibody or antibody-dependent cellular cytotoxic activity. |
| Document Type: Article |
| Language: English |
Addresses:
1. DEPT PUBL HLTH, AIDS PROGRAM, SAN FRANCISCO, CA USA
2. DEPT PUBL HLTH, MICROBIOL LAB, SAN FRANCISCO, CA USA
3. CALIF DEPT HLTH SERV, DIV LABS, VIRAL & RICKETTSIAL DIS LAB, BERKELEY, CA 94704 USA
4. PATHOL INST, BERKELEY, CA USA
5. CTR DIS CONTROL, CTR INFECT DIS, DIV IMMUNOL ONCOL & HEMATOL DIS, ATLANTA, GA 30333 USA
6. CTR DIS CONTROL, CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30333 USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Infectious Diseases |
| IDS Number: FH745 |
| ISSN: 0022-1899 |
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