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FLUORESCENCE INSITU HYBRIDIZATION - APPLICATIONS IN CYTOGENETICS AND GENE-MAPPING
Author(s): TRASK BJ
Source: TRENDS IN GENETICS    Volume: 7    Issue: 5    Pages: 149-154    Published: MAY 1991  
Times Cited: 306     References: 41     
Abstract: Unique sequences, chromosomal subregions, or entire genomes can be specifically highlighted in metaphase or interphase cells by fluorescence in situ hybridization (FISH). This technique can be used to identify chromosomes, detect chromosomal abnormalities or determine the chromosomal location of specific sequences. FISH plays an increasingly important role in a variety of research areas, including cytogenetics, prenatal diagnosis, tumor biology, gene amplification and gene mapping.
Document Type: Article
Language: English
Reprint Address: TRASK, BJ (reprint author), UNIV CALIF LAWRENCE LIVERMORE NATL LAB, DIV BIOMED SCI, LIVERMORE, CA 94550 USA
Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB
Subject Category: Genetics & Heredity
IDS Number: FJ476
ISSN: 0168-9525
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