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| HUPERZINE A - A POTENT ACETYLCHOLINESTERASE INHIBITOR OF USE IN THE TREATMENT OF ALZHEIMERS-DISEASE |
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| Author(s): GEIB SJ, TUCKMANTEL W, KOZIKOWSKI AP |
| Source: ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS Volume: 47 Pages: 824-827 Part: Part 4 Published: APR 15 1991 |
| Times Cited: 13 References: 10 |
| Abstract: Huperzine A, 9-amino-13-ethylidene-11-methyl-4-azatricyclo[7.3.1.0(3,8)]trideca-3(8),6,11-trien-5-one, C15H18N2O, M(r) = 242.32, monoclinic, P2(1)/n, a = 8.8574 (6), b = 12.1833 (7), c = 12.4278 (7) angstrom, beta = 99.956 (5)-degrees, V = 1320.9 (1) angstrom 3, Z = 4, D(x) = 1.22 g cm-3, lambda(Cu K-alpha) = 1.54178 angstrom, mu = 5.75 cm-1, F(000) = 520, T = 296 K, R(F) = 6.30% for 1402 reflections with F(o) greater-than-or-equal-to 5-sigma(F(o)) and 183 parameters. The pyridone ring is planar and the stereochemistry of the C(11)-C(12) double bond is E. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV PITTSBURGH, CHEVRON SCI CTR, DEPT CHEM, PITTSBURGH, PA 15260 USA
2. MINDLABS INC, PITTSBURGH, PA 15238 USA
3. UNIV PITTSBURGH, CHEVRON SCI CTR, DEPT CHEM & BEHAV NEUROSCI, PITTSBURGH, PA 15260 USA |
| Publisher: MUNKSGAARD INT PUBL LTD, 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK |
| Subject Category: Crystallography |
| IDS Number: FJ773 |
| ISSN: 0108-2701 |
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