| | |  | | | | Record from Web of Science® | | | | | | |
| TRANSMISSION BETWEEN PAIRS OF HIPPOCAMPAL SLICE NEURONS - QUANTAL LEVELS, OSCILLATIONS, AND LTP |
|
|
| Author(s): MALINOW R |
| Source: SCIENCE Volume: 252 Issue: 5006 Pages: 722-724 Published: MAY 3 1991 |
| Times Cited: 175 References: 30 |
| Abstract: Long-term potentiation (LTP) of synaptic transmission after coincident pre- and postsynaptic activity is considered a cellular model of changes underlying learning and memory. In intact tissue, LTP has been observed only between populations of neurons, making analysis of mechanisms difficult. Transmission between individual pre- and postsynaptic hippocampal cells was studied, suggesting quantal amplitude distributions with little variability in quantal size. LTP between such pairs is manifested by large, persistent, and synapse-specific potentiation with a shift in amplitude distribution that suggests presynaptic changes. Oscillations in amplitude of transmission, apparently of presynaptic origin, are common and can be triggered by LTP. |
| Document Type: Article |
| Language: English |
| Reprint Address: MALINOW, R (reprint author), UNIV IOWA, DEPT PHYSIOL & BIOPHYS, IOWA CITY, IA 52242 USA |
Addresses:
1. STANFORD UNIV, DEPT MOLEC & CELLULAR PHYSIOL, STANFORD, CA 94305 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: FK185 |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |