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| APOPTOSIS AS A MECHANISM OF CELL-DEATH IN CULTURED T-LYMPHOBLASTS ACUTELY INFECTED WITH HIV-1 |
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| Author(s): TERAI C, KORNBLUTH RS, PAUZA CD, RICHMAN DD, CARSON DA |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 87 Issue: 5 Pages: 1710-1715 Published: MAY 1991 |
| Times Cited: 386 References: 45 |
| Abstract: The mechanisms by which HIV-1 infection kills T lymphocytes are not clearly established. Apoptosis is an internally programmed cell death pathway that may regulate both T cell development and senescence, and that is characterized by cleavage of DNA at internucleosomal regions. The present experiments show that acute HIV-1 infection of MT2 lymphoblasts and activated normal peripheral blood mononuclear cells induces apoptosis. The addition of anti-gp 120 neutralizing antibody, after HIV-1 infection of MT2 cells, permitted sustained high levels of viral replication, but blocked apoptosis and cell death. Apoptosis may account for the direct cytopathologic effects of HIV-1 in T cells. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CALIF SAN DIEGO, DEPT MED, S-045, LA JOLLA, CA 92093 USA
2. UNIV CALIF SAN DIEGO, DEPT PATHOL, LA JOLLA, CA 92093 USA
3. UNIV CALIF SAN DIEGO, SAM & ROSE STEIN INST RES AGING, LA JOLLA, CA 92093 USA
4. UNIV WISCONSIN, SCH MED, DEPT PATHOL & LAB MED, MADISON, WI 53706 USA |
| Publisher: ROCKEFELLER UNIV PRESS, 222 E 70TH STREET, NEW YORK, NY 10021 |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: FK453 |
| ISSN: 0021-9738 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |