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| SYNOVIAL LYMPHOCYTE-T-SPECIFIC IMMUNE-RESPONSE TO CHLAMYDIA-TRACHOMATIS IN REITERS DISEASE |
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| Author(s): SIEPER J, KINGSLEY G, PALACIOSBOIX A, PITZALIS C, TREHARNE J, HUGHES R, KEAT A, PANAYI GS |
| Source: ARTHRITIS AND RHEUMATISM Volume: 34 Issue: 5 Pages: 588-598 Published: MAY 1991 |
| Times Cited: 78 References: 24 |
| Abstract: We studied the lymphocyte proliferative response to Chlamydia trachomatis in Reiter's syndrome (RS) compared with that in other rheumatic diseases. RS patients showed significantly increased C trachomatis-specific synovial fluid (SF) T cell proliferation. Proliferating cells were found in both CD4+ and CD8+ T cell subsets. The SF lymphocyte proliferative response to C trachomatis in RS was inhibited by anti-class I and class II major histocompatibility complex monoclonal antibodies, while the response to tuberculin purified protein derivative was inhibited only by anti-class II monoclonal antibodies. T cell receptor gamma/delta-bearing T cells were not consistently increased in RS SF compared with peripheral blood, nor did such cells consistently expand upon in vitro culture with C trachomatis. Finally, there was no correlation between the cellular immune response and levels of antibody to C trachomatis antigens. Our results indicate that a specific T cell response to C trachomatis within the joint plays a role in the pathogenesis of RS. |
| Document Type: Article |
| Language: English |
Addresses:
1. GUYS HOSP, DEPT MED, RHEUMATOL UNIT, 4TH FLOOR, HUNTS HOUSE, LONDON SE1 9RT, ENGLAND
2. WESTMINSTER MED SCH & HOSP, INST OPHTHALMOL, VIROL SECT, LONDON SW1P 2AP, ENGLAND
3. WESTMINSTER MED SCH & HOSP, DEPT RHEUMATOL, LONDON SW1P 2AP, ENGLAND |
| Publisher: LIPPINCOTT-RAVEN PUBL, 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 |
| Subject Category: Rheumatology |
| IDS Number: FL399 |
| ISSN: 0004-3591 |
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