| | |  | | | | Record from Web of Science® | | | | | | |
| DRUG-EVALUATION OF HUPERZINE-A IN THE TREATMENT OF SENILE MEMORY DISORDERS |
|
|
| Author(s): ZHANG RW, TANG XC, HAN YY, SANG GW, ZHANG YD, MA YX, ZHANG CL, YANG RM |
| Source: ACTA PHARMACOLOGICA SINICA Volume: 12 Issue: 3 Pages: 250-252 Published: MAY 1991 |
| Times Cited: 50 References: 10 |
| Abstract: Huperzine A is an alkoloid which was first isolated from Huperzia serrata (Thumb) Trev by Zhejiang Academy of Medical Sciences and Shanghai Institute of Materia Medica, Chinese Academy of Sciences. It exhibits a significant anticholinesterase activity and has been used on myasthenia gravis patients. The therapeutic effects were studied by random, match and double-blind method on 56 patients of multi-infarct dementia or senile dementia and 104 patients of senile and presenile simple memory disorders. The curative effects were evaluated by Wechsler memory scale. The im dose for multi-infarct dementia was 0.05 mg bid for 4 wk, whereas that for senile and presenile simple memory disorders was 0.03 mg bid for 2 wk. Saline was used on control group. The result showed that the curative effect of huperzine A was significant. Only a few patients felt slight dizziness and this did not affect the therapeutic effects. |
| Document Type: Article |
| Language: Chinese |
Addresses:
1. CHINESE ACAD SCI, SHANGHAI INST MAT MED, SHANGHAI 200031, PEOPLES R CHINA
2. SHANGHAI HUADONG HOSP, SHANGHAI 200040, PEOPLES R CHINA
3. JIAOJIANG PEOPLES HOSP, JIAOJIANG 317700, PEOPLES R CHINA
4. ANHUEI CHINESE TRADIT MED COLL, AFFILIATED HOSP, HEFEI 230000, PEOPLES R CHINA |
| Publisher: ACTA PHARMACOLOGICA SINICA, 294 TAI-YUAN ROAD, SHANGHAI 200031, PEOPLES R CHINA |
| Subject Category: Chemistry, Multidisciplinary; Pharmacology & Pharmacy |
| IDS Number: FL665 |
| ISSN: 0253-9756 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |