| | |  | | | | Record from Web of Science® | | | | | | |
| PERFLUOROCARBON-ASSOCIATED GAS-EXCHANGE |
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| Author(s): FUHRMAN BP, PACZAN PR, DEFRANCISIS M |
| Source: CRITICAL CARE MEDICINE Volume: 19 Issue: 5 Pages: 712-722 Published: MAY 1991 |
| Times Cited: 264 References: 21 |
| Abstract: Background and Methods: Liquid ventilation with oxygenated perfuorocarbon eliminates surface tension due to pulmonary air/fluid interfaces, and improves pulmonary function and gas exchange in surfactant deficiency. In liquid ventilation, perfluorocarbon is oxygenated, purged of CO2, and cycled into and out of the lungs using an investigational device. A new approach, perfluorocarbon-associated gas exchange, uses a conventional ventilator and combines features of liquid ventilation and continuous positive-pressure breathing. In 13 normal piglets, a volume of perfluorocarbon equivalent to the normal functional residual capacity (30 mL/kg) was instilled into the trachea, left in situ, and volume-regulated gas ventilation (FIO2 1.0) was resumed. For 1 hr, perfluorocarbon was continuously bubble-oxygenated within the lungs, where it directly participated in gas exchange. Results: PaO2 and PaCO2 averaged 401 +/- 51 and 40 +/- 4 torr (53.6 +/- 6.8 and 5.3 +/- 0.5 kPa), respectively. Peak airway pressure during perfluorocarbon-associated gas exchange (22 +/- 2 cm H2O at 1 hr) and during continuous, positive-pressure breathing (23 +/- 4 cm H2O) were nearly identical. Venous oxygen saturation and pH were normal (73 +/- 8% and 7.43 +/- 0.05, respectively, at 1 hr).
Conclusions: Perfluorocarbon-associated gas exchange was uniformly well tolerated, and its efficiency approached that of continuous positive-pressure breathing. Applications of perfluorocarbon technology to lung disease may not be limited by existing instrumentation.
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| Document Type: Article |
| Language: English |
| Reprint Address: FUHRMAN, BP (reprint author), CHILDRENS HOSP, DEPT ANESTHESIOL CRIT CARE MED, 3705 5TH AVE, PITTSBURGH, PA 15213 USA |
Addresses:
1. UNIV PITTSBURGH, SCH MED, DEPT ANESTHESIOL CRIT CARE MED, PITTSBURGH, PA 15261 USA
2. UNIV PITTSBURGH, SCH MED, DEPT PEDIAT, PITTSBURGH, PA 15261 USA |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Critical Care Medicine |
| IDS Number: FM131 |
| ISSN: 0090-3493 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |