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| CHARACTERIZATION OF A MURINE GENE EXPRESSED FROM THE INACTIVE X-CHROMOSOME |
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| Author(s): BORSANI G, TONLORENZI R, SIMMLER MC, DANDOLO L, ARNAUD D, CAPRA V, GROMPE M, PIZZUTI A, MUZNY D, LAWRENCE C, WILLARD HF, AVNER P, BALLABIO A |
| Source: NATURE Volume: 351 Issue: 6324 Pages: 325-329 Published: MAY 23 1991 |
| Times Cited: 242 References: 29 |
| Abstract: IN mammals, equal dosage of gene products encoded by the X chromosome in male and female cells is achieved by X inactivation. Although X-chromosome inactivation represents the most extensive example known of long range cis gene regulation, the mechanism by which thousands of gene on only one of a pair of identical chromosomes are turned off is poorly understood. We have recently identified a human gene (XIST) exclusively expressed from the inactive X chromosome 1. Here we report the isolation and characterization of its murine homologue (Xist) which localizes to the mouse X inactivation centre region and is the first murine gene found to be expressed from the inactive X chromosome. Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation. |
| Document Type: Article |
| Language: English |
Addresses:
1. BAYLOR UNIV, INST MOLEC GENET, HOUSTON, TX 77030 USA
2. BAYLOR UNIV, DEPT CELL BIOL, HOUSTON, TX 77030 USA
3. INST PASTEUR, UNITE GENET MOLEC MARINE, F-75724 PARIS 15, FRANCE
4. STANFORD UNIV, MED CTR, SCH MED, DEPT GENET, STANFORD, CA 94305 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: FM976 |
| ISSN: 0028-0836 |
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