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| PREDICTING COILED COILS FROM PROTEIN SEQUENCES |
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| Author(s): LUPAS A, VANDYKE M, STOCK J |
| Source: SCIENCE Volume: 252 Issue: 5009 Pages: 1162-1164 Published: MAY 24 1991 |
| Times Cited: 2,254 References: 31 |
| Abstract: The probability that a residue in a protein is part of a coiled-coil structure was assessed by comparison of its flanking sequences with sequences of known coiled-coil proteins. This method was used to delineate coiled-coil domains in otherwise globular proteins, such as the leucine zipper domains in transcriptional regulators, and to predict regions of discontinuity within coiled-coil structures, such as the hinge region in myosin. More than 200 proteins that probably have coiled-coil domains were identified in GenBank, including alpha- and beta-tubulins, flagellins, G protein beta-subunits, some bacterial transfer RNA synthetases, and members of the heat shock protein (Hsp70) family. |
| Document Type: Article |
| Language: English |
Addresses:
1. PRINCETON UNIV, DEPT MOLEC BIOL, PRINCETON, NJ 08544 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: FN056 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |